059 Possible involvement of innate immune cells expressing the macrophage galactose-type C-type lectin in inflammatory skin diseases

In atopic dermatitis (AD) and psoriasis (Pso), inflammatory skin diseases with a high patient burden, understanding which subsets of dendritic cells (DCs) macrophages (MØs) are involved in the disease pathogenesis remains key to developing effective treatments. Limited subpopulations DCs MØs that thought drive Th2-mediated immune responses mice express macrophage galactose-type C-type lectin (MGL/CLEC10A/CD301). Here, we used specific antibodies detect human MGL healthy (HC) (n=12), AD (n=11), Pso (n=16) skin. HC skin, MGL-positive (MGL+) were present small numbers dermis, but sparse epidermis. lesions, increased MGL+ epidermis dermis infiltrated spongiotic areas lesions. number dermal correlated positively serum levels Thymus Activation Regulated Chemokine (TARC/CCL17), total IgE, TARC+ cell numbers. epidermal cells. Phenotypically, predominantly CD1c+DCs, few CD1a+DCs MØs. 56.9 % 28.6 (Pso) co-stained TARC/CCL17, suggesting portion produce TARC/CCL17. These findings suggest MGL+cells potentially modulation pathogenesis.